Publications

Selected Publications for Eric Olson, Ph.D.

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  1. Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN. April 21, 2017. Control of muscle formation by the fusogenic micropeptide myomixer. Science, 356(6335):323-327. doi: 10.1126/science.aam9361. Epub 2017 Apr 6.
  2. Zhang Y, Long C, Li H, McAnally JR, Baskin KK, Shelton JM, Bassel-Duby R, Olson EN. April 12, 2017. CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice.  Sci Adv, 3(4):e1602814. doi: 10.1126/sciadv.1602814. eCollection 2017 Apr.
  3. Liu N, Garry GA, Li S, Bezprozvannaya S, Sanchez-Ortiz E, Chen B, Shelton JM, Jaichander P, Bassel-Duby R, Olson EN. March 2017. A Twist2-dependent progenitor cell contributes to adult skeletal muscle. Nat Cell Biol, 19(3):202-213. doi: 10.1038/ncb3477. Epub 2017 Feb 20.
  4. Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R, and Olson EN. Dec 6, 2016. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Science Signaling, Vol. 9, Issue 457, pp. ra119 DOI: 10.1126/scisignal.aaj1460.
  5. Anderson KM, Anderson DM, McAnally JR, Shelton JM, Bassel-Duby R and Olson EN. Nov 17, 2016. Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature, 539:433-436. doi:10.1038/nature20128.
  6. Amoasii1 L, Holland W, Sanchez-Ortiz E, Baskin KK, Pearson M, Burgess SC, Nelson BR, Bassel-Duby1 R, Olson EN. Feb 15, 2016. A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism. Genes & Dev, 30(4):434-446. doi: 10.1101/gad.273128.115.
  7. Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN. Jan 22, 2016. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science, 351(6271):400-403. doi: 10.1126/science.aad5725.
  8. Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, Reese AL, McAnally JR, Chen X, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN. Jan 15, 2016. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science, 351(6270):271-5. doi: 10.1126/science.aad4076.
  9. Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN. Feb 12, 2015. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell, 160(4):595-606. doi: 10.1016/j.cell.2015.01.009. Epub 2015 Jan 29.
  10. Long C, McAnally JR, Shelton JM, Mireault AA1, Bassel-Duby R, Olson EN. September 5, 2014. Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA. Science, 345 (6201): 1184-1188; DOI: 10.1126/science.1254445.
  11. Millay DP, Sutherland LB, Bassel-Duby R, Olson EN. August 1, 2014. Myomaker is essential for muscle regeneration. Genes & Development, 28: 1641-1646; doi:10.1101/gad.247205.114.
  12. Olson EN. June 4, 2014. therapeutic targets and biomarkers of cardiovascular disease. Science Translational Medicine, 6(239):239ps3. DOI: 10.1126/scitranslmed.3009008.
  13. Xin M, Olson EN, Bassel-Duby R. August 2013. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nature Reviews Molecular Cell Biology, 14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10.
  14. Millay DP, O'Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN. July 18 2013. Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature, 499(7458):301-5. doi: 10.1038/nature12343.
  15. Van Rooij E and Olson EN. November 2012. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nature Reviews Drug Discovery 11, 860-872.
  16. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. 2012 December 21. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science, 338(6114):1599-603.
  17. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. 2012 May 13. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature, 485(7400):599-604.
  18. Grueter CE, van Rooij E, Johnson BA, Deleon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN. 2012 Apr 27. A A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell, 149, 671-83 (2012).
  19. Mendell JT, Olson EN. 2012 Mar 16. MicroRNAs in stress signaling and human disease. Cell, 148(6):1172-87.
  20. Small EM, Olson EN. 2011. Pervasive roles of microRNAs in cardiovascular biology. Nature, 469(7330):336-42. Review.
  21. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. 2011. Transient regenerative potential of the neonatal mouse heart. Science, 331(6020):1078-80.
  22. Olson EN, Nordheim A. Linking actin dynamics and gene transcription to drive cellular motile functions. 2010 May. Nat Rev Mol Cell Biol, 11(5):353-65. Review.
  23. Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally M, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. 2010. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell, 143(1): 35-45.
  24. Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E and Olson EN. 2010. Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell, 18(3): 282-293.
  25. Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Huang LJ, and Olson EN. 2010. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ. Genes & Development, 24: 1614-1619.
  26. Ning Liu and Olson EN. 2010. MicroRNA Regulatory Networks in Cardiovascular Development. Developmental Cell, 18(4):510-525.
  27. Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN. 2009. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science, 326(5959):1549-54.
  28. van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. 2009. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell, 17(5):662-73.
  29. Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN. 2009. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev, 23(18):2166-78. Epub 2009 Aug 31.
  30. Haberland M, Montgomery RL, Olson EN. 2009. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet, 10(1):32-42. Review.
  31. Haberland M, Mokalled MH, Montgomery RL, Olson EN. 2009. Epigenetic control of skull morphogenesis by histone deacetylase 8.  Genes & Development, 23(14):1625-30.
  32. Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R and Olson EN. 2008. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes & Development, 22(23): 3242-54.
  33. Yi P, Johnson AN, Han Z, Wu J, Olson EN. 2008. Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Developmental Cell, 15(5):704-13.
  34. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, and Olson EN. 2008. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Developmental Cell, 15: 261–271.
  35. Mongomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J,Qi X,Hill JA, Richardson JA, Olson EN. 2007. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes & Development, 21(14): 1790-802.
  36. van Rooij E, Olson EN. 2007. MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. The Journal of Clinical Investigation, 117:2369-76.
  37. van Rooij E, Sutherland LB, Qi X,Richardson JA, Hill J, Olson EN. 2007. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science, 316: 575-579.
  38. Arnold MA, Kim Y, Czubryt MP, Phan D, McAnally J, Qi X, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN. 2007. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Developmental Cell, 12: 377-389.
  39. Yi P, Han Z, Li X, Olson EN. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science. 2006 Sep 1;313(5791):1301-3.
  40. Olson EN. 2006. Gene regulatory networks in the evolution and development of the heart. Science, 313: 1922-1927.
  41. Chang S,Young, B.D, Li, S,Qi, X,Richardson JA, Olson EN. 2006. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell, 126: 321-334.
  42. Song, K, Backs, J,McAnally, J,Qi, S,Richardson JA, Hill, JA, Bassel-Duby, R, and Olson EN. 2006. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell, 125: 453-466.
  43. Bassel-Duby, R and Olson EN. 2006. Signaling pathways in skeletal muscle remodeling. In Annual Review of Biochemistry, 75: 19-37.
  44. Chen, EH and Olson EN. 2005. Unveiling the mechanisms of cell-cell fusion. Science, 308: 369-373.
  45. Nakagawa, O, Arnold, M, Nakagawa, M, Hamada, H, Shelton, JM, Kusano, H, Harris, T.M, Childs, G, Campbell, K.P., Richardson JA, Nishino, I., and Olson EN. 2005. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes & Development, 19, 2066-2077.
  46. Liu, Z-P, Wang Z, and Olson EN. 2005. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Developmental Cell, 9, 261-270.
  47. Vega, RB, Matsuda, K, Oh, J, Barbosa, A, Yang, X, Meadows, E, McAnally, J, Pomajzl, C, Shelton, JM, Richardson JA, Karsenty, G, and Olson EN. 2004. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell, 119: 555-566.
  48. Olson EN. 2004. A decade of discoveries in cardiac biology. Nature Medicine, 10, 467-474.
  49. Frey N, Barrientos T., Shelton JM, Frank D, Rutten H, Gehring D, Kuhn C, Lutz M, Rothermel B, Bassel-Duby R, Richardson JA, Katus HA, Hill JA, Olson EN. 2004. Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nature Medicine, 10, 1336-1343.
  50. Wang Z, Wang D-Z, Hockemeyer, D, McAnally, J, Nordheim, A, and Olson EN. 2004. Myocardin and ternary complex factors compete for SRF during smooth muscle development. Nature, 428: 185-189.
  51. Olson EN, and Schneider, MD 2003. Sizing up the heart: development redux in diseases. Genes & Development, 17, 1937-1956.
  52. Chen, EH, Pryce, BA, Tzeng, JA, Gonzalez, G, and Olson EN. 2003. Control of myoblast fusion by a guanine nucleotide exchange factor, Loner, and its effector ARF6. Cell, 114: 751-762.
  53. Sosic, D, Richardson JA, Yu, K,Ornitz, D.M, and Olson EN. 2003. Twist genes regulate cytokine expression and energy homeostasis through a negative feedback loop that represses NF-B activity. Cell, 112: 169-180.
  54. Naya FJ, Black BL, Wu H, Bassel-Duby R, Richardson JA, Hill JA, Olson EN. 2002. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nature Medicine, 8, 1303-1309.
  55. Lu, J, Hawkins, AF, Bassel-Duby, R, Richardson JA, and Olson EN. 2002. Control of facial muscle development by MyoR and capsulin. Science, 298: 2378-2381.
  56. Shin CH, Liu ZP, Passier R, Zhang CL, Wang D.Z, Harris T.M, Yamagishi H, Richardson JA, Childs, G, and Olson EN. 2002. Modulation of cardiac development by HOP, an unusual homeodomain that antagonizes the activity of serum response factor. Cell, 110: 725-735.
  57. Zhang, CL, McKinsey TA, Chang S, Antos, CA, Hill, JA, and Olson EN. 2002. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell, 110: 479-488.
  58. Yanagisawa, H, Davis, E.C, Starcher, B.C, Ouchi, T., Yanagisawa, M, Richardson JA and Olson EN. 2002. Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo. Nature, 415: 168-171.
  59. Chen EH, Olson EN. 2001. Antisocial, an intracellular adaptor protein, is required for myoblast fusion in DrosophilaDevelopmental Cell. 1, 705-715.
  60. Wang D-Z, Chang P, Wang Z, Small E, Krieg PA, Olson EN. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell, 105: 851-862.
  61. McKinsey TA, Zhang CL, Lu J,and Olson EN. 2000. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature, 408: 106-111.
  62. Srivastava D and Olson EN. 2000. A genetic blueprint for cardiac development: Implications for human heart disease. Nature, 407: 221-226.
  63. Olson EN. and Williams RS. 2000. Calcineurin signaling and muscle remodeling. Cell, 101: 689-692.
  64. Molkentin JD Lu, J,Antos, CL, Markham B, Richardson J, Robbins J, Grant S and Olson EN. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell, 93: 215-228.
  65. Fishman MC and Olson EN. 1997. Parsing the Heart: Genetic modules for organ assembly. Cell, 91: 153-156.
  66. Molkentin JD, Black BL, Martin JF, and Olson EN. 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell, 83: 1125-1136.