Research

Research

More information regarding current projects can be found on the left. Below are recent publications from our laboratory:

 

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D. Science 2017.

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.

Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol 2016.

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.

Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Nat Chem Biol 2016.