cubeRandom Resistance to Anti-Cancer Therapy Our goal is to elucidate mechanisms of resistance to current anti-cancer therapies, such as hormone therapy for prostate cancer.
cubeRandom Novel Biomarkers We aim to identify novel biomarkers for hormone-therapy response via CRISPR/shRNA-based library screens.
cubeRandom Combination Therapies We seek to determine the molecular mechanism of lineage-plasticity-driven resistance and develop combination therapies to overcome it.
cubeRandom Cancer Cell Lineage Plasticity We have identified a novel mechanism of antiandrogen resistance in prostate cancer driven by lineage plasticity, or “identity fraud."