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Resistance to Anti-Cancer Therapy
Our goal is to elucidate mechanisms of resistance to current anti-cancer therapies, such as hormone therapy for prostate cancer.
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Novel Biomarkers
We aim to identify novel biomarkers for hormone-therapy response via CRISPR/shRNA-based library screens.
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Combination Therapies
We seek to determine the molecular mechanism of lineage-plasticity-driven resistance and develop combination therapies to overcome it.
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Cancer Cell Lineage Plasticity
We have identified a novel mechanism of antiandrogen resistance in prostate cancer driven by lineage plasticity, or “identity fraud."