Jessica Moreland, M.D.
I am a physician-scientist with clinical practice in the Pediatric Intensive Care Unit, thus caring for patients with a wide range of systemic inflammatory processes has informed and focused my laboratory interests.
My research program is centrally focused around the theme of neutrophilic inflammation, in the context of human disease, with a specific interest in the neutrophil NADPH oxidase. For a number of years, we have sought to define the role of the neutrophil NADPH oxidase (Nox2) in neutrophil priming by infectious and inflammatory stimuli. Our laboratory identified intracellular NADPH oxidase-derived ROS as critical mediators of endotoxin priming, and demonstrated regulation of Nox2 in this setting by the ion transporter ClC-3. My laboratory also studies the role of neutrophil priming in translational studies focused on infants undergoing cardiopulmonary bypass and during other acute and chronic inflammatory processes.
Most recently, we have become interested in how pro-inflammatory stimuli and cellular outputs are balanced by anti-inflammatory responses to restore host homeostasis. The concept of compartmentalization of Nox-derived ROS giving rise to localized signaling is a central theme of our current work, and we are currently focused on a novel anti-inflammatory role for Nox2.
Renee Potera, M.D.
I am a physician scientist in the division of pediatric critical care medicine with primary research interests in innate immunity and acute lung injury, with a specific interest in the role of NADPH oxidase 2 (Nox2).
This is primarily studied in the context of a clinically relevant disease process, the systemic inflammatory response syndrome (SIRS). Recently published studies have demonstrated that Nox2 is required to limit and resolve inflammation in the lung following SIRS.
I am currently investigating the role of Nox2 in alveolar macrophages in the development and resolution of acute lung injury following systemic inflammatory events.