Extensive Molecular Profiling of Lung and Breast Cancer Cell Lines
Through multiple collaborations we are generating large molecular datasets on our lung and breast cancer cell line panels (about 150 NSCLC lines, 50 SCLC lines, 40 breast cancer lines). These include:
- Expression microarrays
- SNP arrays, which can generate copy number information (collaboration with MD Anderson Cancer Center and Baylor College of Medicine)
- Methylation profiling on 450,000 CpG sites (collaboration with Genentech)
- Exome sequencing (collaboration with Baylor College of Medicine ).
This wealth of information (several terabytes of data) can lead to better understanding of how these cancers develop and how to treat them. They are being applied to several areas of research such as finding sets of genes that correlate with molecular or clinical phenotypes such as sensitivity or resistance to therapy, or finding vulnerabilities in cancer cells that can then be targeted with specific drugs.
In addition, these datasets fuel a wide range of cancer research projects and collaborations both at UT Southwestern and with other institutions.