Research

Research

Research in the Mendelson lab focuses on molecular mechanisms involved in developmental and hormonal regulation of key genes and signaling pathways in perinatal biology and female reproduction. We study genetic and epigenetic mechanisms in differentiation of the surfactant-producing cells of fetal lung and placental syncytiotrophoblast, as well as mechanisms underlying the maintenance of myometrial quiescence during pregnancy and the initiation of uterine contractility leading to term and preterm labor. Our studies support an important role of maturation of the fetal lung and synthesis of lung surfactant lipids and proteins in the timing of birth.