MRI Publications

MRI Publications

Oximetry and oxygen enhanced MRI/Pre-clinical

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging. H. Zhou, Z. Zhang, R. Denney, J. S. Williams, J. Gerberich, S. Stojadinovic, D. Saha, J. M. Shelton, and R. P. Mason, Oncotarget, 8: 37464-37477, 2017

Developing Oxygen-Enhanced Magnetic Resonance Imaging as a Prognostic Biomarker of Radiation Response. D. A. White, Z. Zhang, L. Li, J. Gerberich, S. Stojadinovic, P. Peschke, R. P. Mason, Cancer Letters, 380, 69–77 (2016) doi:10.1016/j.canlet.2016.06.003

Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors. C. Glowa, C. P. Karger, S. Brons, D. Zhao, R. P. Mason, P. E. Huber, J. Debus, P. Peschke, Cancer Letters 378, (2) 97–103 (2016) doi:10.1016/j.canlet.2016.05.013

Tumor radio-sensitivity assessment by means of volume data and magnetic resonance indices measured on prostate tumor bearing rats.  A. Belfatto, D. A. White, R. P. Mason, Z. Zhang, S. Stojadinovic, G. Baroni, and P. Cerveri, Med. Phys. 43, 1275 (2016); doi: 10.1118/1.4941746

A Noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water. Z. Zhang, R. R. Hallac, P. Peschke, R. P. Mason, Magn. Reson. Med., online DOI 10.1002/mrm.24691 Feb. 2013.

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response. R. R. Hallac, H. Zhou, R. Pidikiti, K. Song, S. Stojadinovic, D. Zhao, T. Solberg, P. Peschke, and R. P. Mason, Magn. Reson. Med., accepted (2013) DOI 10.1002/mrm.24846.

New Frontiers and Developing Applications in 19F NMR, J.X. Yu, R. R. Hallac, S. Chiguru, and R. P. Mason, Prog. NMR Spectrosc., 70 25–49 (2013).

Quantitative tissue oxygen measurement in multiple organs using (19) F MRI in a rat model. Liu S., Shah S.J., Wilmes L.J., Feiner J., Kodibagkar V.D., Wendland M.F., Mason R.P., Hylton N., Hopf H.W., Rollins M.D. Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011 Jun.

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death. Kucejova B., Sunny N.E., Nguyen A.D., Hallac R., Fu X., Peña-Llopis S., Mason R.P., Deberardinis R.J., Xie X.J., Debose-Boyd R., Kodibagkar V.D., Burgess S.C., Brugarolas J. Oncogene 2011 May 30 18 2147-60.

Hexamethyldisiloxane-based nanoprobes for (1) H MRI oximetry. Gulaka P..K., Rastogi U., McKay M.A., Wang X., Mason R.P., Kodibagkar V.D. NMR in biomedicine 2011 Mar.

Comparison of 1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation. Zhao D., Jiang L., Hahn E.W., Mason R.P. Magn Reson Med 2009 Aug 62 2 357-64.

Proton imaging of siloxanes to map tissue oxygenation levels (PISTOL): a tool for quantitative tissue oximetry. Kodibagkar V.D., Wang X., Pacheco-Torres J., Gulaka P., Mason R.P. NMR Biomed 2008 Oct 21 8 899-907.

Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor. Bourke V.A., Zhao D., Gilio J., Chang C.H., Jiang L., Hahn E.W., Mason R.P. Int. J. Radiat. Oncol. Biol. Phys. 2007 Mar 67 4 1179-86.

Tumor physiologic response to combretastatin A4 phosphate assessed by MRI. Zhao D., Jiang L., Hahn E.W., Mason R.P. Int. J. Radiat. Oncol. Biol. Phys. 2005 Jul 62 3 872-80.

Comparison of BOLD contrast and Gd-DTPA dynamic contrast-enhanced imaging in rat prostate tumor. Jiang L., Zhao D., Constantinescu A., Mason R.P. Magn Reson Med 2004 May 51 5 953-60.

Tumor oxygen dynamics: correlation of in vivo MRI with histological findings. Zhao D., Ran S.., Constantinescu A., Hahn E.W., Mason R.P. Neoplasia 2003 Jul-Aug 5 4 308-18.

Dynamic response of breast tumor oxygenation to hyperoxic respiratory challenge monitored with three oxygen-sensitive parameters. Gu Y., Bourke V.A., Kim J.G., Constantinescu A., Mason R.P., Liu H. Appl Opt 2003 Jun 42 16 2960-7.

Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor. Zhao D., Constantinescu A., Chang C.H., Hahn E.W., Mason R.P. Radiat. Res.2003 May 159 5 621-31.

Interplay of tumor vascular oxygenation and tumor pO2 observed using near-infrared spectroscopy, an oxygen needle electrode, and 19F MR pO2 mapping. Kim J.G., Zhao D., Song Y., Constantinescu A., Mason R.P., Liu H. J Biomed Opt 2003 Jan 8 1 53-62.

Tumor oxygen dynamics: comparison of 19F MR EPI and frequency domain NIR spectroscopy. Song Y., Worden K.L., Jiang X., Zhao D., Constantinescu A., Liu H., Mason R.P. Adv. Exp. Med. Biol.2003 530 225-36.

Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction. Mason R.P., Constantinescu A., Ran S.., Thorpe P.E. Adv. Exp. Med. Biol. 2003 530 197-204.

Tumor oximetry: comparison of 19F MR EPI and electrodes. Mason R.P., Hunjan S., Constantinescu A., Song Y., Zhao D., Hahn E.W., Antich P.P., Peschke P. Adv. Exp. Med. Biol.2003 530 19-27.

Dynamic breast tumor oximetry: the development of prognostic radiology. Song Y., Constantinescu A., Mason R.P. Technol. Cancer Res. Treat. 2002 Dec 1 6 471-8.

Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge. Zhao D., Constantinescu A., Hahn E.W., Mason R.P. Int. J. Radiat. Oncol. Biol. Phys. 2002 Jul 53 3 744-56.

Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology. Mason R.P., Ran S.., Thorpe P.E. J. Cell. Biochem. Suppl. 2002 39 45-53.

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Translation to man

Incorporating Oxygen-Enhanced MRI into Multi-Parametric Assessment of Human Prostate Cancer.  H. Zhou , R. R. Hallac, Q. Yuan, Y. Ding, Z. Zhang, X.-J. Xie, F. Francis, C. G. Roehrborn, R. D. Sims, D. N. Costa, G. V. Raj and R. P. Mason, DIAGNOSTICS  7 (3): 48 : SEP 2017

"Simultaneous measurement of TOLD and BOLD effects in abdominal tissue oxygenation level studies." Y. Ding, R. P. Mason, R. W. McColl, Q. Yuan, R. R. Hallac, R. D. Sims, P. T. Weatherall, J. Magn. Reson. Imaging (JMRI) 2013 Jun 7. doi: 10.1002/jmri.24006.

Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T. Hallac R.R, Ding Y., Yuan Q., McColl R.W.,Lea J., Sims R.D., Weatherall P.T., Mason R.P. NMR Biomed 2012 Dec 25 12 1321-30.

Blood oxygenation level-dependent (BOLD) contrast magnetic resonance imaging (MRI) for prediction of breast cancer chemotherapy response: A pilot study. Jiang L., Weatherall P.T., McColl R.W., Tripathy D., Mason R.P. J Magn Reson Imaging 2012 Nov.



6-Trifluoromethylpyridoxine: novel 19F NMR pH indicator for in vivo detection. Yu J..X., Cui W., Bourke V.A., Mason R.P. J. Med. Chem. 2012 Aug 55 15 6814-21.

Enzyme Activity

Novel S-Gal® analogs as 1H MRI reporters for in vivo detection of β-galactosidase,” P. K. Gulaka, J.-X. Yu, L. Liu, R. P. Mason and V. D. Kodibagkar, "Magn. Reson. Imaging 31(6):1006-1011 (2013).

"Novel Fe3+-based 1H MRI "β-Galactosidase reporter molecules." J.-X. Yu, P. K. Gulaka, L. Liu, V. D. Kodibagkar, R. P. Mason, ChemPlusChem.,77 (5), 370-378 (2012) DOI: 10.1002/cplu.201100072.

Dual 19F/1H MR gene reporter molecules for in vivo detection of ß-Galactosidase. Yu J..X., Kodibagkar V.D., Hallac R.R, Liu L., Mason R.P. Bioconjug. Chem. 2012 Mar 23 3 596-603.

S-Gal, a novel 1H MRI reporter for beta-galactosidase. Cui W., Liu L., Kodibagkar V.D., Mason R.P. Magn Reson Med 2010 Jul 64 1 65-71.

A 19F-NMR approach using reporter molecule pairs to assess beta-galactosidase in human xenograft tumors in vivo. Yu J..X., Kodibagkar V.D., Liu L., Mason R.P. NMR Biomed 2008 Aug 21 7 704-12.

19F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl beta-D-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse. Liu L., Kodibagkar V.D., Yu J..X., Mason R.P. FASEB J. 2007 Jul 21 9 2014-9.
19F: a versatile reporter for non-invasive physiology and pharmacology using magnetic resonance. Yu J..X., Kodibagkar V.D., Cui W., Mason R.P. Curr. Med. Chem.2005 12 7 819-48.

Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression. Yu J., Otten P., Ma Z, Cui W., Liu L., Mason R.P. Bioconjug. Chem.2004 Nov-Dec 15 6 1334-41.

Novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-beta-D-galactopyranoside as a prototype reporter molecule for beta-galactosidase. Cui W., Otten P., Li Y, Koeneman K.S., Yu J., Mason R.P. Magn Reson Med 2004 Mar 51 3 616-20.

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