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Publications

Publications

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy. Hernandez G, Luo T, Javed TA, Wen L, Kalwat MA, Vale K, Ammouri F, Husain SZ, Kliewer SA, Mangelsdorf DJ. Sci Transl Med. 2020 Jan 8;12(525). pii: eaay5186. doi: 10.1126/scitranslmed.aay5186. PMID: 31915301

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2019 Aug 1;33(15-16):1083-1094. doi: 10.1101/gad.326868.119. Epub 2019 Jul 11. PMID: 31296559

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21. Kliewer SA, Mangelsdorf DJ. Cell Metab. 2019 Feb 5;29(2):246-253. doi: 10.1016/j.cmet.2019.01.004. Review. PMID: 30726758

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice. Katafuchi T, Holland WL, Kollipara RK, Kittler R, Mangelsdorf DJ, Kliewer SA. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12102-12111. doi: 10.1073/pnas.1814522115. Epub 2018 Nov 12. PMID: 30420515

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol. Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA. Cell Metab. 2018 Jun 5;27(6):1338-1347.e4. doi: 10.1016/j.cmet.2018.04.001. Epub 2018 Apr 12. PMID: 29657029

Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice. Patton JB, Bonne-Année S, Deckman J, Hess JA, Torigian A, Nolan TJ, Wang Z, Kliewer SA, Durham AC, Lee JJ, Eberhard ML, Mangelsdorf DJ, Lok JB, Abraham D. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):204-209. doi: 10.1073/pnas.1712235114. Epub 2017 Dec 4. PMID: 29203662

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia. Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ. Cell Metab. 2017 Nov 7;26(5):709-718.e3. doi: 10.1016/j.cmet.2017.09.005. Epub 2017 Oct 5. PMID: 28988823

Nuclear receptors: emerging drug targets for parasitic diseases. Wang Z, Schaffer NE, Kliewer SA, Mangelsdorf DJ. J Clin Invest. 2017 Apr 3;127(4):1165-1171. doi: 10.1172/JCI88890. Epub 2017 Feb 6. Review. PMID: 28165341

FGF21 Is an Exocrine Pancreas Secretagogue. Coate KC, Hernandez G, Thorne CA, Sun S, Le TDV, Vale K, Kliewer SA, Mangelsdorf DJ. Cell Metab. 2017 Feb 7;25(2):472-480. doi: 10.1016/j.cmet.2016.12.004. Epub 2017 Jan 12. PMID: 28089565

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Harst P, van Duijn CM, Marques-Vidal P, Vollenweider P, Wareham NJ, Whitfield JB, Wilson J, Wolffenbuttel B, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377. Epub 2016 Nov 28. PMID: 27911795

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. Sondhi V, Owen BM, Liu J, Chomic R, Kliewer SA, Hughes BA, Arlt W, Mangelsdorf DJ, Auchus RJ. Mol Endocrinol. 2016 Apr;30(4):469-78. doi: 10.1210/me.2015-1282. Epub 2016 Mar 14. PMID: 26974035

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1026-31. doi: 10.1073/pnas.1514511113. Epub 2016 Jan 11. PMID: 26755598

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid. Albarqi MM, Stoltzfus JD, Pilgrim AA, Nolan TJ, Wang Z, Kliewer SA, Mangelsdorf DJ, Lok JB. PLoS Pathog. 2016 Jan 4;12(1):e1005358. doi: 10.1371/journal.ppat.1005358. eCollection 2016 Jan. PMID: 26727267

FGF21 Regulates Sweet and Alcohol Preference. Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA. Cell Metab. 2016 Feb 9;23(2):344-9. doi: 10.1016/j.cmet.2015.12.008. Epub 2015 Dec 24. PMID: 26724861

Bile Acids as Hormones: The FXR-FGF15/19 Pathway. Kliewer SA, Mangelsdorf DJ. Dig Dis. 2015;33(3):327-31. doi: 10.1159/000371670. Epub 2015 May 27. Review. PMID: 26045265

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. Katafuchi T, Esterházy D, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ. Cell Metab. 2015 Jun 2;21(6):898-904. doi: 10.1016/j.cmet.2015.05.004. PMID: 26039452

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes. Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA. PLoS Genet. 2015 Mar 16;11(3):e1005027. doi: 10.1371/journal.pgen.1005027. eCollection 2015 Mar. PMID: 25774872

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop. Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Mol Endocrinol. 2015 Feb;29(2):213-23. doi: 10.1210/me.2014-1259. Epub 2014 Dec 11. PMID: 25495872

SnapShot: Hormones of the gastrointestinal tract. Coate KC, Kliewer SA, Mangelsdorf DJ. Cell. 2014 Dec 4;159(6):1478.e1. doi: 10.1016/j.cell.2014.11.026. PMID: 25480303

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Owen BM, Mangelsdorf DJ, Kliewer SA. Trends Endocrinol Metab. 2015 Jan;26(1):22-9. doi: 10.1016/j.tem.2014.10.002. Epub 2014 Dec 1. Review. PMID: 25476453