Assistant Director of the TRUST Program
Department of Radiology, UT Southwestern
Dr. Jacques Lux obtained his doctorate in chemistry at the University of Strasbourg under the guidance of Nobel laureate Prof. Jean-Pierre Sauvage. His doctoral projects aimed at designing and developing synthetic molecular machines reminiscent of biological systems. Dr. Lux conducted postdoctoral research at the faculty of pharmacy in Strasbourg, where he developed activatable optical probes for the detection of viral RNA. He then came to the U.S. to train in supramolecular chemistry in Prof. Julius Rebek Jr.’s laboratory at the Scripps Research Institute in La Jolla, California. Dr. Lux did additional postdoctoral research at the University of California-San Diego, applying his skills in organic and coordination chemistry to the field of material science, before becoming a Research Scientist to develop and translate theranostics for imaging and drug delivery.
While at UCSD, he designed and synthetized a novel MR contrast agent that incorporated gadolinium that was chelated and linked to hydrogel nanoparticles (nanogels). The advantage of this strategy is not only the development of high relaxivity T1 agents, but also minimizing demetallation. The versatility of this platform was demonstrated by incorporating 64Cu instead of gadolinium that allowed for in vivo PET/CT imaging of cancer. Dr. Lux also participated in the development of novel activatable optical nanoprobes for the detection of inflammation.
His current research interests lie in the development of novel nanomedicine platforms to diagnose and treat disease in vivo noninvasively with the long-term objective of developing clinically translatable theranostic agents. Dr. Lux received in November the 2017 Docstars Award by The Cary Council in recognition and support of promising early-stage research.