Lenette graduated with a B.A. in the Honors Program with a major in Biology and minor in Asian Studies from Swarthmore College in 2002 where she worked in the laboratory of Elizabeth Vallen on yeast cell cycle regulation. As part of the Medical Scientist Training Program at Case Western Reserve University, she earned a Ph.D. in the Molecular Virology Program in 2009 and M.D. in 2010. Her graduate work in the laboratory of Ganes Sen centered on dsRNA mediated signaling and innate immunity in the context of paramyxovirus infections. She completed an internship and residency in Internal Medicine at New York Presbyterian – Weill Cornell in 2013 and a fellowship in Infectious Diseases in the Partners program at Massachusetts General Hospital and Brigham and Women’s Hospital in 2015. Her postdoctoral research in the laboratories of Sarah Fortune at the Harvard T.H. Chan School of Public Health and Galit Alter at the Ragon Institute of MGH, MIT, and Harvard focused on delineating the humoral landscape of immune responses to Mycobacterium tuberculosis. During these years she was an Instructor at HMS and Assistant in Medicine at MGH in the Infectious Diseases Division seeing patients in the hospital and clinic. Lenette joined the Division of Infectious Diseases and Geographic Medicine at UT Southwestern in 2019 with a clinical practice primarily at Parkland and a research lab aimed at identifying the mechanisms by which antibodies mediate the host microbial interface in tuberculosis and beyond.