Study identifying molecular mechanisms driving Schwannoma development featured on the cover of JCI Insight

The Le Lab reports on molecular mechanisms driving the development of Schwannoma, a tumor of the Schwann cell in patients with Neurofibromatosis Type 2 and Schwannomatosis. They provide direct genetic evidence that schwannoma formation is mediated by dysregulation of the Hippo pathway and modified by RAS/MAPK signaling. This paper made the cover of JCI Insight.

The cover image shows Hoxb7 lineages (Yellow/Red), a sub-population of Schwann cells (Green), in the peripheral nerves that give rise to Schwannoma in this study.

JCI Inisght Cover