Welcome to the Le Laboratory in the Department of Dermatology and Simmons Comprehensive Cancer Center. One aim of our lab is to help train the next generation of scientists and physicians.


Cancer Biology

Our main mission is to understand mechanisms that initiate Schwann cell tumors and drive their malignant transformation as well as to translate our discoveries into new therapies for individuals with neurofibromatosis.


Tumor Cell of Origin

Our laboratory deciphers the cellular origin of neurofibroma to elucidate tumor biology and to generate tumor models for therapeutic development.


Tumor Microenvironment

Our laboratory investigates how genetic and tumor microenvironmental events interplay to regulate neurofibroma development.


Developmental Biology

Our laboratory has uncovered the identity of cells that directly give rise to hair and mechanisms that cause hair to turn gray - findings that could one day help identify possible treatments for balding and hair graying.

Meet the PI

Dr. Le received his Ph.D. degree in Immunology and Molecular Genetics, and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA).

Lu Q. Le, M.D., Ph.D.

About Us

Our laboratory has a diverse group of students and scientists who came from different corners of the world with distinct backgrounds but common scientific interests.
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Our research spans the fields of Cancer Biology, Developmental Biology, and Stem Cell Biology that focuses on neural-crest derived tissue development, regeneration, and tumorigenesis, in particular, the biology of neurofibromatosis.
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Meet the Lab

Lu Le lab members

Lab Members