Keun is a postdoctoral fellow in the Kraus lab. Keun’s research interests are in the role of nuclear NAD+ signaling in the control of transcription.
He earned a B.Sc. degree from Seoul National University, Korea in 2009 and received his Ph.D. from University of Texas Southwestern Medical Center in 2017.
Ryu, K. W., Nandu, T., Kim, J., Challa, S., DeBerardinis, R. J., Kraus, W. L. (2018) Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis. Science, 6289 (360), doi:10.1126/science.aan5780
Luo, X., Ryu K.W., Kim D.-K., Nandu T., Medina C.J., Gupte R., Gibson B.A., Soccio R.E., Yu Y., Gupte R., Kraus W.L.(2017) PARP-1 controls the adipogenic transcription program by PARylating C/EPBβ and modulating its transcriptional activity. Molecular Cell, 65:260-271. doi:10.1016/j.molcel.2016.11.015
Ryu, K. W., & Kraus, W. L. (2016). Who put the "A" in ATP? Generation of ATP from ADP-Ribose in the nucleus for hormone-dependent gene regulation. Molecular Cell, 63(3), 349-351. doi:10.1016/j.molcel.2016.07.018
Zhang, T., Berrocal, J. G., Yao, J., DuMond, M. E., Krishnakumar, R., Ruhl, D. D., . . . Kraus, W. L. (2012). Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase. J Biol Chem, 287(15), 12405-12416. doi:10.1074/jbc.M111.304469