About Us

Amberlyn Wands, Ph.D.

 

Education

Ph.D. in Chemistry, 2010, University of Michigan

B.S. in Chemistry 2002, University of Texas at Dallas

Publications

CA Toleman, MA Schumacher, S-H Yu, W Zeng, NJ Cox, TJ Smith, EJ Soderblom, AM Wands, JJ Kohler, M Boyce.  Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U. S. A. (2018). doi: 10.1073/pnas.1722437115

J Cervin, AM Wands, A Casselbrant, H Wu, S Krishnamurthy, A Cvjetkovic, J Estelius, B Dedic, A Sethi, K-L, Wallom, R Riise, M Bäckström, V Wallenius, FM Platt, M Lebens, S Teneberg, L Fändriks, JJ Kohler, U Yrlid. GM1 ganglioside-independent intoxication by cholera toxin. PLoS Pathogens (2018). 14:e1006862 * featured on PLoS Cholera Channel

AM Wands, J Cervin, H Huang, Y Zhang, G Youn, CA Brautigam, M Matson Dzebo, P Björklund, V Wallenius, DK Bright, CS Bennett, P Wittung-Stafshede, NS Sampson, U Yrlid, JJ Kohler. Fucosylated molecules competitively interfere with cholera toxin binding to host cells. ACS Infect. Dis. (2018). 4:758-770  * highlighted in ScienceDaily; www.sciencedaily.com/releases/2018/03/180309100653.htm

Nam D. Pham, Poh-Choo Pang, Soumya Krishnamurthy, Amberlyn M. Wands, Paola Grassi, Anne Dell, Stuart M. Haslam, and Jennifer J. Kohler. Effects of Altered Sialic Acid Biosynthesis on N-linked Glycan Branching and Cell Surface Interactions. Journal of Biological Chemistry 2017 Apr 19. pii: jbc.M116.764597

Wands AM, Fujita A, McCombs JE, Cervin J, Dedic B, Rodriguez AC, Nischan N, Bond MR, Mettlen M, Trudgian DC, Lemoff A, Quiding-Järbrink M, Gustavsson B, Steentoft C, Clausen H, Mirzaei H, Teneberg S, Yrlid U, Kohler JJ. Fucosylation and protein glycosylation create functional receptors for cholera toxin. Elife, 2015 Oct 29; 4:e09545.

Yu S-H, Wands AM, & Kohler JJ. Photoaffinity probes for studying carbohydrate biology. Journal of Carbohydrate Chemistry (2012) 31: 325-352.

Yu S-H, Boyce M, Wands AM, Bond MR, Bertozzi, CR, & Kohler, JJ.Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners, Proc. Natl. Acad. Sci. USA, (2012) 109: 4834-4839.

Wands AM, Wang N, Lum JK, Hsieh J, Fierke CA, Mapp AK. Transient-state Kinetic Analysis of Transcriptional Activator•DNA Complexes Interacting with a Key Coactivator. J. Biol. Chem., 2011, 286 (18), 16238-45.

Majmudar, C.Y., Lee, L.W., Lancia, J.K., Nwokoye, A., Wang, Q., Wands, A.M., Wang, L., Mapp, A.K. Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator. J. Am. Chem. Soc., 2009, 131 (40), 14240-2.

Wands, A.M. and Mapp, A.K. Transcription-Based Therapeutics, in Wiley Encyclopedia of Chemical Biology, John Wiley & Sons, Inc. Hoboken, NJ (2008).