Research

Research

The formation and maintenance of long-term memories for episodes and spaces are vital for daily life. The goal of our laboratory is to provide a biophysically-based mechanistic understanding of neural process for learning and memory in the mouse brain by linking the elementary information processing and representation mechanisms of individual neurons and their microcircuits to animal behaviors in the entorhinal cortical hippocampal network. We also try to understand how learning and memory processing is impaired under psychotic conditions. To address these question, we will examine neural circuit mechanisms for the behavior-dependent optimization of brain’s spatiotemporal metrics by using mouse circuit genetics, retrograde trans-synaptic tracing, in vivo calcium imaging, electrophysiology in vivo and in vitro, and circuits/cell-type specific activity manipulating analysis.