Novel Mouse Models of Head and Neck Cancers

Head and neck cancers encompass a heterogeneous group of cancers from multiple primary anatomic and tissue sites. Treatment consists of combination surgery, radiation, and chemotherapy with toxic side effects and often disfigurement. A dearth of research tools and reagents, including endogenous mouse models, has slowed advances in head and neck cancer diagnosis and treatment.

We have identified a novel endogenous mouse model of head and neck cancer that metastasizes to lymph nodes and the lung, one of the primary sites of metastases in human head and neck cancer.

This mouse model represents a new tool to dissect the molecular mechanisms and biological behavior of head and neck cancers, to identify prognostic and predictive biomarkers and to identify novel drug targets that may lead to new therapeutic regimens to treat HNC.