Publications for Wen Jiang, M.D., Ph.D.

Feng M, Jiang W, Betty Kim YS, Zhang Cheng, Fu Yang-Xin, Weissman I. Phagocytosis checkpoints as new targets for cancer immunotherapy. Nature Reviews Cancer, 2019 Aug 28. PMID: 31462760.

Chen Y, Liu X, Yuan H, von Roemeling CA, Qie Y, Knight JA, Wang Y, Yun K, Jiang W,* Kim BYS. Therapeutic remodeling of the tumor microenvironment enhances nanoparticle delivery. Advanced Science, doi:10.1002/advs.201802070 (2019).

Wang Y, Liu ZG, Huang YH, Li J, Kim BYS, Story MD, Jiang W. The reciprocity cancer immunotherapy and radiotherapy. Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-18-2581 (2018).

Liu Z, Jiang W (co-first author), Nam J, Moon JJ, Kim BYS. Immune modulating nanomedicine for cancer therapy. Nano Letters, 18, 6655-6659 (2018).

Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Mutant LKB1 confers enhanced radiosensitization in combination with trametinib in KRAS-mutant non-small cell lung cancer. Clinical Cancer Research, 24(22):5744-5756 (2018).

Tang C, Jiang W, Yap TA. Efficacy and toxic effects of cancer immunotherapy combinations: a double-edged sword. JAMA Oncology, 4(8), 1116-1117 (2018).

Zheng X, Fang Z, Wang X, Zhang C, Yin R, Wen C, Liu X, Deng S, Zhou P, Hu H, Chen X, Wang X, Zhao Y, Xin L, Lin SH, Kim BYS, Jiang W, Wu Q, Huang YH. Increased vessel perfusion predicts the therapeutic efficacy of immune checkpoint blockade. Journal of Clinical Investigation, 128, 2104-2115 (2018).

Huang YH, Kim BYS, Chan CK, Hahn SM, Weissman IL, Jiang W. Improving immune-vascular crosstalk for cancer immunotherapy. Nature Rev Immunology, 18, 195-203 (2018).

Wang Y, Gudikote J, Yan J, Deng W, Jiang W, Li N, Ye R, Hobbs BP, Wang J, Swisher SG, Fujimoto J, Wistuba II, Komaki R, Heymach JV, Lin SH. RAD50 expression is associated with poor clinical outcomes after radiotherapy in resected non-small cell lung cancer. Clin Cancer Res, 24, 341-350 (2017).

Chow KH, Park HJ, George J, Yamamoto K, Gallup AD, Graber J, Chen YX, Jiang W, Steindler D, Neilson EG, Kim BYS, Yun K. S100A4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma. Cancer Research, 77(19), 5360-5373 (2017).

Yuan H, Jiang W (co-first author),* von Roemeling CA, Qie Y, Liu X, Chen Y, Wharen RE, Yun K, Bu G, Knutson KL, Kim BYS. Multivalent bi-specific nano-bioconjugate engager for targeted cancer immunotherapy. Nature Nanotechnology, 12(8), 763-769 (2017).

Jiang W,von Roemeling C, Qie Y, Chen Y, Liu X, Chen J, Kim BYS. Designing next generation cancer nanomedicine for immuno-oncology. Nature Biomed Eng, 1(2), 0029 (2017).

Jiang W,* Yuan H, Chan CK, von Roemeling C, Yan Z, Weissman IL, Kim BYS. Lessons from immuno-oncology: a new era for cancer nanomedicine? Nature Rev Drug Discovery, 16, 169-170 (2017).

Jiang W. A tale of two disciplines. Nature Nanotechnology, 11, 732 (2016).

von Roemling C, Jiang W (co-first author),* Chan CK, Weissman IL, Kim BYS. Breaking bown the barriers to precision cancer nanomedicine. Trends in Biotechnol (Cell Press), 35, 159-171 (2017).

Jiang W,* Chan CK, Weissman IL, Kim BYS, Hahn SM. Immunogenic priming of tumor microenvironment with radiotherapy. Trends in Cancer (Cell Press), 2, 638-645 (2016).

Qie Y, Yuan H, Chen Y, Von Roemeling C, Liu X, Kim Y, Knight JA, Jiang W, Kim BYS. Surface modification of nanoparticle enables selective evasion of phagocytosis by distinct macrophage phenotypes. Scientific Reports, 6, 26269 (2016).

Jiang W, An Y, Huang Y, Kim BYS. Remodel tumor vasculature to enhance the delivery of intermediate-sized nanoparticles into solid tumors. ACS Nano, 9, 8689-96 (2015).

Liu R, Jiang W, Walkey CD, Chan WCW, Cohen Y. Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties. Nanoscale, 7, 9664-9675 (2015).

Chan C, Lindau P, Jiang W (co-first author), Chen J, Zhang L, Chen C-C, Seita J, Sahoo D, Kim J, Lee A, Park S, Nag D, Gong Y, Kulkarni S, Luppen C, Theologis A, Wan D, DeBoer A, Seo E, Vincent-Tompkins J, Loh K, Walmsley G, Kraft D, Wu J, Longaker M, Weissman IL. A clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. PNAS, 110, 12643-12648 (2013).

Wong CR, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Fukumura D, Bawendi MG. Multistage nanoparticle delivery system demonstrates deep penetration into tumor tissue through MMP-activated size change. PNAS, 108, 2426 (2011).

Liu W, Greytak AB, Lee J, Park J, Wong CR, Marshall L, Jiang W, Curtin P, Ting AY, Nocera DG, Jain RK, Bawendi MG. Compact biocompatible and derivatizable quantum dots via RAFT-mediated synthesis of coordinating imidazole-based random copolymer ligand. Journal American Chemical Society, 132, 472-483 (2010).

Jiang W, Kim BYS, Rutka JT, Chan WCW. Nanoparticle-mediated cellular response is size-dependent. Nature Nanotechnology, 3, 145-150 (2008).

Kim BYS, Jiang W (co-first author), Oreopolous J, Yip CM, Rutka JT, Chan WCW. Biodegradable quantum dot nanocomposites enable live cell labelling and imaging of cytoplasmic targets. Nano Letters, 8, 3887-3892 (2008).

Jiang W, Kim BYS, Rutka JT, Chan WCW. Advances and challenges of nanotechnology based drug delivery systems. Expert Opinion in Drug Delivery, 4, 621-633 (2008).

Jiang W, Singhal A, Kim BYS, Zheng J, Rutka JT, Wang C, Chan WCW. Assessing near-infrared quantum dots for deep tissue, organ, animal imaging. Journal of the Association for Laboratory Automation, 13, 6-12 (2007).

Jiang W, Singhal A, Zheng J, Wang C, Chan WCW. Optimizing the synthesis of red to near-IR-emitting CdS-capped CdTexSe1-x alloyed quantum dots for biomedical imaging. Chemistry of Materials, 18, 4845-4854 (2006).

Jiang W, Mardyani S, Fischer H, Chan WCW. Design and characterization of lysine cross-linked mercapto-acid biocompatible quantum dots. Chemistry of Materials, 18, 872-878 (2006).

Gryczynki I, Malicka J, Jiang W, Fischer H, Chan WCW, Gryczynki Z, Grudzinski W, Lakowicz JR. Surface-plasmon-coupled emission of quantum dots. Journal of Physical Chemistry B, 109, 1088-1093 (2005).

Jiang W, Papa E, Fischer H, Mardyani S, Chan WCW. Semiconductor quantum dots as contrast agents for whole animal imaging. Trends in Biotechnol (Cell Press), 22, 607-609 (2004).

[1] Co-corresponding author