Multi-scale analysis of single molecule dynamics and cellular output

                  Integrin single-molecule dynamics vs. cell edge protrusion activity

Recent advances in high-resolution microscopy have made it possible to follow the dynamics of single molecules. Establishing the relationship between molecular behaviors and cell-level outputs remains however a major challenge.

We are developing integrated imaging, image analysis, and data analysis frameworks that bridge the gap between the spatial and temporal scales of single-molecule behavior and cell-level events. In collaboration with the Galbraith lab at Oregon Health and Science University, we are applying our analyses to study the dynamics of integrin molecules (key receptors in cell-matrix adhesion) in the context of cell edge protrusion activity.