The Jain Lab is broadly interested in the impact of sex hormones, primarily estrogen and progesterone, on airway diseases and host immune responses to infections by agents such as Pseudomonas aeruginosa.
The airway diseases we focus on are cystic fibrosis (CF) and other forms of bronchiectasis. CF is an autosomal recessive inherited disease. Morbidity and mortality is primarily driven by progressive airway obstruction, inflammation, and recurrent respiratory infections.
Despite the equal prevalence in both sexes, CF females have a shortened life expectancy relative to males. In addition, females acquire respiratory infections at an earlier age than males and have a more rapid decline in health.
Similar patterns have been described in women versus men with other airway diseases such as chronic obstructive pulmonary disease, asthma, and non-CF related bronchiectasis.
Our research team is dedicated to understanding the role of sex hormones on host immune responses to infection, specifically Pseudomonas aeruginosa, using murine and cell-based models. We also plan to study the impact of sex hormones on susceptibility to non-tuberculous mycobacterial infections.
Our long-term goal is to build the foundation for novel hormone-modulating therapeutics to treat airway diseases.