Hormonal effect on responses to infection

Stained cells
Immunofluorescent staining of airway epithelial cells grown at air-surface liquid. Tight junction visible through stain of ZO-1 in green and nuclear staining in blue.

We use airway epithelial cells grown at an air-liquid interface to understand the impact of estrogen and progesterone on cell responses to Pseudomonas aeruginosa in planktonic and biofilm form.

We also study the impact of sex hormones on neutrophil responses to Pseudomonas aeruginosa and the interaction of the epithelium and neutrophils under these conditions.