Next Generation Small Animal Radiation Research Platform

Small Animal Radiation Research (SARR) is of paramount importance for the advancement of human radiotherapy (RT) by serving as a critical counterpart to perform comprehensive preclinical studies on a large number of subjects under controlled experimental conditions at low costs. Current-generation SARR irradiators, developed in the past decade, may not keep pace with technology advancements in human RT. We are developing and translating a next-generation SARR platform with novel imaging methods (dual energy cone beam CT and PET), intensity modulated radiotherapy capability, and a high-performance GPU-based treatment planning system. These novel features are expected to improve SARR research relevance to human RT by delivering treatments of clinical quality, to support exploration in modern RT by offering technical freedom to realize novel imaging and therapy approaches, and to increase research efficiency by enhancing computational speed and workflow. 

  Funding Support:
  1. “Next generation small animal radiation research platform,” NIH/NCI 1R37CA21463901, 02/2018 - 01/2023.
  2. “Diversity supplement, Next generation small animal radiation research platform,” NIH/NCI 1R37CA21463901-S1, 07/2018 - 01/2020.