Multifaceted approaches

We leverage our strengths in biochemistry, chemical biology and drug discovery to develop an understanding of ocular disease caused by protein misfolding. Read more


Unique assay development

We use a series of novel assays which allow us to gain insight into how proteins fold and misfold. One assay uses a luciferase isolated from the marine conepod, Gaussia princeps (pictured). Read more


Insight into cures from rare diseases

We study rare, early-onset protein misfolding diseases such as Malattia Leventinese (pictured) to better understand more prominent, but phenotypically similar diseases, such as age-related macular degeneration. Read more


A focus on the extracellular matrix

The extracellular matrix (ECM) is a critical component for a number of retinal processes including support of the RPE and the photoreceptors. We are interested in understanding the importance of particular ECM proteins in the eye and how mutations in these proteins ultimately result in pathogenesis. Read more

Meet the PI

John Hulleman, Ph.D.
John Hulleman, Ph.D.

Available Positions

The Hulleman Laboratory currently has an opening for a talented and productive postdoctoral researcher. Contact us for more information.

Research Highlight

The Hulleman Laboratory is committed to understanding and rectifying the underlying causes of inherited and idiopathic eye disorders caused by protein misfolding. Read more.

Contact Us

Get in touch with us for more information about our team, research, job opportunities, etc.