Histone Deacetylases (HDAc) as Novel Therapeutic Targets

HDAC diagram
Four-chamber sections of hearts

Recent evidence has implicated histone acetylation as a mechanism governing cardiac gene expression and pathological growth of the heart. Working with a model of pressure-overload cardiac hypertrophy, we have found that suppression of histone deacetylases (HDACs) blunts hypertrophy. Importantly, despite significant attenuation of hypertrophic growth, cardiac function and general health are preserved, suggesting that HDACs regulate a pathological type of hypertrophy.