Electrical Remodeling

Electrical Remodeling diagram

Cardiac hypertrophy and failure are associated with substantial risk of malignant ventricular arrhythmia and consequent sudden cardiac death. Pathological prolongation of the ventricular action potential contributes importantly to the propensity to arrhythmia. In a model of pressure-overload cardiac hypertrophy, we have found that increased expression and function of the cardiac L-type Ca2+ channel underlies this action potential prolongation. Work is underway to decipher transcriptional control of channel expression, post-translational regulation of channel function, and apparent coupling of the channel with the transient-outward K+ channel.