Circadian Rhythms

MCIP1 Protein levels in heart

Many types of heart disease present variably during the course of the 24-hour day. Within the cardiac myocyte, several hundred genes manifest significant diurnal variation in expression. Recent work in our lab has demonstrated that environmental stimuli are capable of "resetting" this cardiac clock, just as environmental stimulation (in the form of light) can reset the circadian pacemaker in the brain. Work is underway to decipher the molecular basis of the environmental responsiveness of the cardiac clock.