Cooperativity broadly manifests itself from biology to society. We designed a cooperative nanoparticle system which displays all-or-nothing phase transition, and are using the system to study cooperativity at molecular and nano scales.
Nano-immuno-oncology is an emerging cross field that harnesses nanotechnology’s unique synergy with immunology to advance cancer immunotherapy. We have developed a nanoparticle vaccine capable of binding to and activating STING and generating efficacious CD8 T cell responses.
Tumors are known for their aberrant metabolic phenotype. We are investigating the link between acidotic metabolism and immune suppression, and looking into molecular and cellular mechanisms which may be perturbed therapeutically.
Obtaining tumor-free surgical margins is important to achieve disease-free survival while minimizing removal of normal tissues preserves quality of life. We have developed transistor-like pH nanosensors to achieve binary delineation of tumor margins for image-guided cancer surgery.