Research

Research

Molecular Cooperativity

Molecular Cooperativity

Cooperativity broadly manifests itself from biology to society. We designed a cooperative nanoparticle system which displays all-or-nothing phase transition, and are using the system to study cooperativity at molecular and nano scales.

 
Polymeric STING Activation

Nano-Immuno-Oncology

Nano-immuno-oncology is an emerging cross field that harnesses nanotechnology’s unique synergy with immunology to advance cancer immunotherapy. We have developed a nanoparticle vaccine capable of binding to and activating STING and generating efficacious CD8 T cell responses.

 
Single Cell Technologies

Tumor & Immune Metabolism

Tumors are known for their aberrant metabolic phenotype. We are investigating the link between acidotic metabolism and immune suppression, and looking into molecular and cellular mechanisms which may be perturbed therapeutically.

 
Cancer Imaging & Surgery

Cancer Imaging & Surgery

Obtaining tumor-free surgical margins is important to achieve disease-free survival while minimizing removal of normal tissues preserves quality of life. We have developed transistor-like pH nanosensors to achieve binary delineation of tumor margins for image-guided cancer surgery.