About Us

Meet the PI

Luke Engelking, M.D., Ph.D.
Luke Engelking, M.D., Ph.D.

Luke Engelking, M.D., Ph.D.

Assistant Professor,
Internal Medicine, Center for Human Nutrition, Molecular Genetics

Dr. Engelking is originally from Houston, Texas and first came to UT Southwestern for joint MD/PhD training (2000-2007), where he studied cholesterol and fat metabolism under the tutelage of Nobel Laureates Goldstein and Brown. He then completed his clinical training in internal medicine at Massachusetts General Hospital (2007-2010), an affiliate of Harvard Medical School.  Drawn by the opportunity to study lipid metabolism in the intestine, he returned to UT Southwestern for clinical and research fellowships in gastroenterology and hepatology (2010-2014) and thereafter joined the faculty of the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Genetics along with the Center for Human Nutrition. His current research interests include understanding the roles that lipids, particularly cholesterol, play in the growth of intestinal cells both in normal health and in states of uncontrolled growth, such as intestinal cancers like colorectal cancer. He practices adult gastroenterology and serves as a teaching attending of fellows, residents, and students at Parkland Memorial Hospital.  He also serves as the director of the GI Genetics Clinic at Parkland, a clinic subspecialized in the care of patients with inherited disorders of polyposis and colorectal cancer, particularly Lynch syndrome and Familial Adenomatous Polyposis syndrome.



    Medical School

  •         UT Southwestern Medical School (2007)


  •         Massachusetts General Hospital (2010), Internal Medicine


  •         UT Southwestern Medical Center (2014), Gastroenterology


Research Interest

  • Cholesterol and Fat Metabolism
  • Inherited Colon Cancer and Polyposis Syndromes, Lynch Syndrome, Familial Adenomatous Polyposis Syndrome
  • Intestinal Stem Cell Function
  • SREBP, Scap and Insig Proteins


Honors & Awards

  • Disease-Oriented Clinical Scholar
    UT Southwestern (2014)
  • Distinguished Researcher's Award
    President's Research Council (2014)
  • Research Scholar in Liver Disease
    North American Gilead Sciences (2014)
  • Alpha Omega Alpha Honor Medical Society
    UT Southwestern (2007)
  • Summa cum laude
    Texas A&M University (2000)
  • University Honors
    Texas A&M University (2000)
  • University Undergraduate Research Fellow
    Texas A&M University (2000)