Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We investigate the regulation of lipid biosynthesis using a variety of disciplines including molecular and cell biology, mouse models and organoid technologies. The laboratory has a long-standing interest in the biologic functions of SREBP pathway genes, including Scap and Insigs, which were discovered by Dr. Engelking’s longtime mentors, Nobel laureates Drs. Michael S. Brown and Joseph L. Goldstein.
The laboratory is part of the Center for Human Nutrition, Department of Molecular Genetics, and the Division of Digestive and Liver Diseases in the Department of Internal Medicine. The facilities are located in the South Campus of UT Southwestern, on the fifth floor of the Green Science Building (L).