The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD Elife 2018 May 7
CIPHER: a flexible and extensive workflow platform for integrative next-generation sequencing data analysis and genomic regulatory element prediction.
Guzman C, D'Orso I BMC Bioinformatics 2017 Aug 18 1 363
Tandem Affinity Purification of Protein Complexes from Eukaryotic Cells.
Ma Z, Fung V, D'Orso I J Vis Exp 2017 Jan 119
Transcription Elongation Control by the 7SK snRNP Complex: Releasing the Pause.
McNamara RP, Bacon CW, D'Orso I Cell Cycle 2016 May 0
7SKiing on chromatin: move globally, act locally.
D'Orso I RNA Biol 2016 Apr 0
Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II.
McNamara RP, Guzman C, Reeder JE, D'Orso I Genom Data 2016 Mar 7 250-5
KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.
McNamara RP, Reeder JE, McMillan EA, Bacon CW, McCann JL, D'Orso I Mol. Cell 2016 Jan 61 1 39-53
Functional interplay between PPM1G and the transcription elongation machinery.
Gudipaty SA, D'Orso I RNA Dis 2016 3 1
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells.
Reeder JE, Kwak YT, McNamara RP, Forst CV, D'Orso I Elife 2015 Oct 4
PPM1G binds 7SK RNA and Hexim1 to block P-TEFb assembly into the 7SK snRNP and sustain transcription elongation.
Gudipaty SA, McNamara RP, Morton EL, D'Orso I Mol. Cell. Biol. 2015 Aug