Research Overview

We are interested in a fundamental question in life sciences: How do cells make decisions?

Bulk measurements masks cell behavior.

To answer this question we have developed a framework that combines single-cell microscopy, genetic manipulation, and mathematical modeling. We have used this framework to determine principles that govern cell fate decisions in budding yeast.

This approach makes it possible to study cellular signaling and decision making with very high precision in real time, allowing us to use quantitative measurements to gain qualitative insights into how cell networks execute decisions.

Our main model organism is budding yeast, but we are also interested in other systems.