Publications

Publications

60. Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

Wang, S.; Han, L.; Han, J.; Li, P.; Ding, Q.; Zhang, Q.-J.; Liu, Z.-P.; Chen, C,; Yu, Y.

Nat.Chem.Biol. 2019, 15, 1223-1231

 

59. Stereoselective Fatty Acylation Is Essential for the Release of Lipidated WNT Proteins from the Acyltransferase Porcupine (PORCN)

Tuladhar, R.; Yarravarapu, N.; Ma, Y.; Zhang, C.; Herbert, J.; Kim, J.; Chen, C.; Lum, L.

J. Biol. Chem. 2019, 294, 6273–6282 [PMID: 30737280] [PDF] (supporting info)

 

58. Installation of a Cancer Promoting WNT/SIX1 Signaling Axis by the Oncofusion Protein MLL-AF9

Zhang, L.-s.; Kang, X.; Lu, J.; Zhang, Y.; Wu, X.; Wu, G.; Zheng, J.; Tuladhar, R.; Shi, H.; Wang, Q.; Morlock, L.; Yao, H.; Huang, L. J.-s.; Maire, P.; Kim, J.; Williams, N.; Xu, J.; Chen, C.; Zhang, C. C.; Lum, L.

EBioMedicine 2019, 39, 145–158 [PMID: 30528456] (supporting info)

 

57. Rapid Access to the Core Skeleton of the [3 + 2]-Type Dimeric Pyrrole–Imidazole Alkaloids by Triplet Ketone-Mediated C–H Functionalization (Invited Article for Tetrahedron Symposium-in-Print "Biogenetic Considerations in Complex Synthesis")

You, L.; Chen, C.

Tetrahedron 2018, 74, 769–772 [PMID: 29622843] (supporting info)

 

56. Natural Products as Inspiration for the Development of New Synthetic Methods (Invited Article in honor of Prof. Tien-Yau Luh's 70th Birthday)

Ma, Z.; Chen, C.

J. Chin. Chem. Soc. 2018, 1, 43–59 [PMID: 29430058] [PDF]

 

55. A Synthetic Combinatorial Approach to Disabling Deviant Hedgehog Signaling

Fan, C. W.; Yarravarapu, N.; Shi, H.; Kulak, O.; Kim, J.; Chen, C.; Lum, L.

Sci. Rep. 2018, 8, 1133 [PMID: 29348431] (supporting info)

 

54. Ketone-Catalyzed Photochemical C(sp3)–H Chlorination (Invited Article in honor of Prof. Ang Li's 2017 Tetrahedron Young Investigator Award)

Han, L.; Xia, J.-B.; You, L.; Chen, C.

Tetrahedron 2017, 73, 3696–3701 [PMID: 28717256] (supporting info)

 

53. cGAS Is Essential for the Antitumor Effect of Immune Checkpoint Blockade

Wang, H.; Hu, S.; Chen, X.; Shi, H.; Chen, C.; Sun, Li; Chen, Z. J.

Proc. Natl. Acad. Sci. 2017, 114, 1637–1642 [PMID: 28137885] [PDF] (supporting info)

 

52. Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter

Ma, Z.; You, L.; Chen, C.

J. Org. Chem. 2017, 82, 731–736 [PMID: 27933858] [PDF] (supporting info)

 

51. Development of a Triazole Class of Highly Potent Porcn Inhibitors

You, L.; Zhang, C.; Yarravarapu, N.; Morlock, L.; Wang, X.-L.; Zhang, L.; Williams, N. S.; Lum, L.; Chen, C.

Bioorg. Med. Chem. Lett. 2016, 26, 5891–5895 [PMID: 27876319] (supporting info)

 

50. Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles (Invited Article for the Reactions of Hydrocarbons and other C-H Compounds Special Issue)

Zhang, C.; You, L.; Chen, C.

Molecules 2016, 20, 1268 [PMID: 27669198]

 

49. The past, present, and future of the Yang Reaction (Invited Review Article)

Chen, C.

Org. Biomol. Chem. 2016, 14, 8641–8647 [PMID: 27517138] [PDF]

 

48. Asymmetric Synthesis of Axinellamines A and B

Ma, Z.; Wang, X.; Ma, Y.; Chen, C.

Angew. Chem. Int. Ed. 2016, 55, 4763–4766 [PMID: 27037993] [PDF] (supporting info) (Synfacts highlight)

 

47. Chemical Disruption of Wnt-Dependent Cell Fate Decision-Making Mechanisms in Cancer and Regenerative Medicine (Invited Review Article)

Lum, L.; Chen, C.

Curr. Med. Chem. 2015, 22, 4091–4103 [PMID: 26310918]

 

46. Identification and Characterization of β-Sitosterol Target Proteins (Invited Article for the 25th Anniversary Symposium-in-Print "Recent Advances in Medicinal Chemistry and Chemical Biology")

Lomenick, B.; Shi, H.; Huang, J.; Chen, C.

Bioorg. Med. Chem. Lett. 2015, 25, 4976–4979 [PMID: 25804720] (supporting info)

 

45. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Fu, X.; Chin, R. M.; Vergnes, L.; Hwang, H.; Deng, G.; Xing, Y.; Pai, M. Y.; Li, S.; Ta, L.; Fazlollahi, F.; Chen, C.; Prins, R. M.; Teitell, M. A.; Nathanson, D. A.; Lai, A.; Faull, K. F.; Jiang, M.; Clarke, S. G.; Cloughesy, T. F.; Graeber, T. G.; Braas, D.; Christofk, H. R.; Jung, M. E.; Reue, K.; Huang J.

Cell Metab. 2015, 22, 508–515 [PMID: 26190651] [PDF] (supporting info)

 

44. Molecular Basis for the Specific Recognition of the Metazoan Cyclic GMP-AMP by the Innate Immune Adaptor Protein STING

Shi, H.; Wu, J.; Chen, Z. J.; Chen, C.

Proc. Natl. Acad. Sci. 2015, 112, 8947–8952 [PMID: 26150511] [PDF] (supporting info)

 

43. Syntheses of Sceptrins and Nakamuric Acid and Insights into the Biosyntheses of Pyrrole–Imidazole Dimers

Wang, X.-L.; Gao, Y.; Ma, Z.; Rodriguez, R. A.; Yu, Z.-X.; Chen, C.

Org. Chem. Front. 2015, 2, 978–984 [PMID: 26328059] [PDF] (supporting info)

 

42. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

Kulak, O.; Chen, H.; Holohan, B.; Wu, X.; He, H.; Borek, D.; Otwinowski, Z.; Yamaguchi, K.; Garofalo, L. A.; Ma, Z.; Wright, W.; Chen, C.; Shay, J. W.; Zhang, X.; Lum, L.

Mol. Cell Biol. 2015, 35, 2425–2435 [PMID: 25939383] [PDF] (supporting info)

 

41. Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F (Invited Article for Tetrahedron Letters Symposium-in-Print in Memory of Prof. Harry Wasserman)

Shi, H.; De, S.; Wang, Q.; Gao, S.; Wang, X.; Chen, C.

Tetrahedron Lett. 2015, 56, 3225–3227 [PMID: 26097263] (supporting info)

 

40. An Approach for the Synthesis of Nakamuric Acid (Invited Article for Tetrahedron Symposium-in-Print "Synthesis of Indole/Pyrrole-Containing Natural Products")

Wang, X.-L.; Chen, C.

Tetrahedron, 2015, 71, 3690–3693 [PMID: 25983349] (supporting info)

 

39. Syntheses of Cyclic Guanidine-Containing Natural Products (Invited Review Article)

Ma, Y.; De, S.; Chen, C.

Tetrahedron 2015, 71, 1145–1173 [PMID: 25684829]

 

38. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation

Fan, C.-W.; Chen, B.; Franco, I.; Lu, J.; Shi, H.; Wei, S.; Wang, C.; Wu, X.; Tang, W.; Roth, M. G.; Williams, N. S.; Hirsch, E.; Chen, C.; Lum, L.

Chem. Biol. 2014, 21, 1680–1689 [PMID: 25484239] [PDF] (supporting info)

 

37. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence

Ma, Z.; Wang, X.-L.; Wang, X.; Rodriguez, R. A.; Moore, C. E.; Gao, S.; Tan, X.; Ma, Y.; Rheingold, A. L.; Baran, P. S.; Chen, C.

Science 2014, 346, 219–224 [PMID: 25301624] [HTML] [PDF] (response to comment) (supporting info)

 

36. Visible Light-Promoted Metal-Free sp3-C–H Fluorination

Xia, J.-B.; Zhu, C.; Chen, C.

Chem. Commun. 2014, 50, 11701–11704 [PMID: 25143256] [PDF] (supporting info)

 

35. Dimeric Pyrrole–Imidazole Alkaloids: Synthetic Approaches and Biosynthetic Hypotheses (Invited Review Article)

Wang, X.; Ma, Z.; Wang, X.-L.; De, S.; Ma, Y.; Chen, C.

Chem. Commun. 2014, 50, 8628–8639 [PMID: 24828265] [PDF]

 

34. Vanadium-Catalyzed C(sp3)–H Fluorination Reactions

Xia, J.-B.; Ma, Y.; Chen, C.

Org. Chem. Front. 2014, 1, 468–472 [PMID: 24976971] [PDF] (supporting info)

 

33. A Simple Method for the Electrophilic Cyanation of Secondary Amines

Zhu, C.; Xia, J.-B.; Chen, C.

Org. Lett. 2014, 16, 247–250 [PMID: 24313859] [PDF] (supporting info)

 

32. Vanadium-Catalyzed Oxidative Strecker Reaction: α-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines

Zhu, C.; Xia, J.-B.; Chen, C.

Tetrahedron Lett. 2014, 55, 232–234 [PMID: 24415804] (supporting info)

 

31. Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination

Xia, J.-B.; Zhu, C.; Chen, C.

J. Am. Chem. Soc. 2013, 135, 17494–17500 [PMID: 24180320] [PDF] (supporting info) (Synfacts highlight)

 

30. Stromal-Epithelial Crosstalk Regulates Kidney Progenitor Cell Differentiation

Das, A.; Tanigawa, S.; Karner, C. M.; Xin, M.; Lum, L.; Chen, C.; Olson, E. N.; Perantoni, A. O.; Carroll, T. J.

Nat. Cell Biol. 2013, 15, 1035–1044 [PMID: 23974041] [PDF] (supporting info)

 

29. Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING

Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z. J.

Mol. Cell 2013, 51, 226–235 [PMID: 23747010] [PDF] (supporting info)

 

28. The Development of Highly Potent Inhibitors for Porcupine

Wang, X.-L.; Moon, J.; Dodge, M. E.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N. S.; Amatruda, J.; Carroll, T. J.; Lum, L.; Chen, C.

J. Med. Chem. 2013, 56, 2700–2704 [PMID: 23477365] [PDF] (supporting info)

 

27. Cyclic-GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J.; Sun, L.; Chen, X.; Du, F.; Shi, H.; Chen, C.; Chen, Z. J.

Science 2013, 339, 826–830 [PMID: 23258412] [PDF] (supporting info)(Perspective)

 

26. Nakiterpiosin (Invited Book Chapter)

Gao, S.; Chen. C.

In Total Synthesis of Natural Products–At the Frontiers of Organic Chemistry; Li, J. J., Corey, E. J., Eds.; Springer-Verlag: Berlin/Heidelberg, 2013; pp 25–38

 

25. A Biomimetic Route for the Construction of the [4+2] and [3+2] Core Skeletons of the Dimeric Pyrrole–Imidazole Alkaloids and the Asymmetric Synthesis of Ageliferins

Wang, X.; Wang, X.-L.; Tan, X.; Lu, J.; Cormier, K. W.; Ma, Z.; Chen. C.

J. Am. Chem. Soc. 2012, 134, 18834–18842 [PMID: 23072663] [PDF] (correction) (supporting info)

 

24. The Chemistry and Biology of Nakiterpiosin (Invited Review Article)

Gao, S.; Wang, Q.; Wang, G.; Lomenick, B; Liu, J.; Fan, C.-W.; Deng, L.-W.; Huang, J.; Lum, L.; Chen. C.

Synlett 2012, 23, 2298–2310 [PMID: 23226922] [PDF]

 

23. A Highly Selective Vanadium Catalyst for Benzylic C–H Oxidation

Xia, J.; Cormier, K. W.; Chen, C.

Chem. Sci. 2012, 3, 2240–2245 [PMID: 22712051] [PDF] (supporting info)

 

22. Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane Bound O-Acyltransferase Porcupine

Dodge, M. E.; Moon, J.; Tuladhar, R.; Lu, J.; Jacob, L. S.; Zhang, L.-s.; Shi, H.; Wang, X.-L.; Moro, E.; Mongera, A.; Argenton, F.; Karner, C. M.; Carroll, T. J.; Chen, C.; Amatruda, J. F.; Lum, L.

J. Biol. Chem. 2012, 287, 23246–23254 [PMID: 22593577] [PDF]

 

21. In Vivo Wnt Signaling Tracing through a Transgenic Biosensor Fish Reveals Novel Activity Domains

Moro, E.; Ozhan-Kizil, G.; Mongera, A.; Beis, D.; Wierzbicki, C.; Young, R. M.; Bournele, D.; Domenichini, A.; Valdivia, L. E.; Lum, L.; Chen, C.; Amatruda, J. F.; Tiso, N.; Weidinger, G.; Argenton, F.

Dev. Biol. 2012, 366, 327–340 [PMID: 22546689]

 

20. Asymmetric Synthesis of Ageliferin

Wang, X.; Ma, Z.; Lu, J.; Tan, X.; Chen, C.

J. Am. Chem. Soc. 2011, 133, 15350–15353 [PMID: 21888421] [PDF] (supporting info)

 

19. Canonical Wnt9b Signaling Balances Progenitor Cell Expansion and Differentiation During Kidney Development

Karner, C. M.; Das, A.; Ma, Z.; Self, M.; Chen, C.; Lum, L.; Oliver, G.; Carroll T. J.

Development 2011, 138, 1247–1257 [PMID: 21350016] [PDF]

 

18. Revisiting the Kinnel–Scheuer Hypothesis for the Biosynthesis of Palau'amine (Invited Article for the Emerging Investigator Special Issue)

Ma, Z.; Lu, J.; Wang, X.; Chen, C.

Chem. Commun. 2011, 47, 427–429 [PMID: 20848010] [PDF] (supporting info)

 

17. Tankyrase Is Necessary for Canonical Wnt Signaling during Kidney Development

Karner, C. M.; Michael Dodge, C. E.; Ma, Z.; Lu, J.; Chen, C.; Lum, L.; Carroll, T. J.

Dev. Dyn. 2010, 239, 2014–2023 [PMID: 20549720] [PDF]

 

16. Chemical and Biological Studies of Nakiterpiosin and Nakiterpiosinone

Gao, S.; Wang, Q.; Huang, L. J.; Lum, L.; Chen, C.

J. Am. Chem. Soc. 2010, 132, 371–383 [PMID: 20000429] [PDF] (supporting info)

 

15. Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response (Invited Article in honor of Prof. Carlos Barbas III's 2009 Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry)

Lu, J.; Ma, Z.; Hsieh, J.-C.; Fan, C.-W.; Chen, B.; Longgood, J. C.; Williams, N. S.; Amatruda, J. F.; Lum, L.; Chen, C.

Bioorg. Med. Chem. Lett. 2009, 19, 3825–3827 [PMID: 19410457]

 

14. Synthesis and Structure Revision of Nakiterpiosin

Gao, S.; Wang, Q.; Chen, C.

J. Am. Chem. Soc. 2009, 131, 1410–1412 [PMID: 18998640] [PDF] (supporting info) (cover picture) (Synfacts highlight)

 

13. Small Molecule-mediated Disruption of Wnt-dependent Signal Transduction in Tissue Regeneration and Cancer

Chen, B.; Dodge, M. E.; Tang, W.; Lu, J.; Ma, Z.; Fan, C.-W.; Wei, S.; Hao, W.; Kilgore, J. A.; Williams, N. S.; Roth, M. G.; Amatruda, J. F.; Chen, C.; Lum, L.

Nat. Chem. Biol. 2009, 5, 100–107 [PMID: 19125156] [PDF] (supporting info) (News and Views)

 

12. On the Potent Inhibitors of the Hedgehog Signaling Pathway (Invited Condensation and Commentary)

Chen, C.

Chemtracts–Org. Chem. 2008, 21, 150–154

 

11. Nickel-Catalyzed Carbonylative Negishi Cross-Coupling Reactions

Wang, Q.; Chen, C.

Tetrahedron Lett. 2008, 49, 2916–2921 (Synfacts highlight)

 

10. An Approach to the Core Skeleton of Lancifodilactone F

Wang, Q.; Chen, C.

Org. Lett. 2008, 10, 1223–1226 [PMID: 18303901] [PDF] (supporting info)

 

9.  Palladium-Catalyzed Direct Functionalization of Imidazolinone: Synthesis of Dibromophakellstatin

Lu, J.; Tan, X.; Chen, C.

J. Am. Chem. Soc. 2007, 129, 7768–7769 [PMID: 17539649] [PDF] (Addition) (supporting info)

 

8.  Regiocontrol in Manganese(III)-Mediated Oxidative Heterobicyclizations: Access to the Core Skeletons of roidin Dimers

Tan, X.; Chen, C.

Angew. Chem. Int. Ed. 2006, 45, 4345–4348 [PMID: 16739146] [PDF] (supporting info)

 

7.  Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids

Chen, C.; Li, X.; Neumann, C. S.; Lo, M. M.-C.; Schreiber, S. L.

Angew. Chem. Int. Ed. 2005, 44, 2249–2252 [PMID: 15747386] [PDF] (supporting info)

 

6.  Label-free Detection of Small-molecule–Protein Interactions by Using Nanosensors

Wang, W. U.; Chen, C.; Lin, K.-h.; Fang, Y.; Lieber, C. M.

Proc. Natl. Acad. Sci. 2005, 102, 3208–3212 [PMID: 15716362] [PDF]

 

5.  Catalytic Asymmetric [3+2] Cycloaddition of Azomethine Ylides. Development of a Versatile Stepwise, Three-Component Reaction for Diversity-Oriented Synthesis

Chen, C.; Li, X.; Schreiber, S. L.

J. Am. Chem. Soc. 2003, 125, 10174–10175 [PMID: 12926931] [PDF] (supporting info)

 

4.  Abnormal and Regioselective Wacker Oxidation of 1,5-Diene

Ho, T.-L.; Chang, M.; Chen, C.

Tetrahedron Lett. 2003, 44, 6955–6957

 

3.  Synthesis of (+)-CP-263,114

Chen, C.; Layton, M. E.; Sheehan, S. M.; Shair, M. D.

J. Am. Chem. Soc. 2000, 122, 7424–7425 [PDF] (supporting info)

 

2.  Chelation-Assisted Regioselective C–O Bond Cleavage Reactions of Acetals by Grignard Reagents. A General Procedure for the Regioselective Synthesis of Protected Polyols Having One Free Hydroxy Group

Cheng, W.-L.; Shaw, Y.-J.; Yeh, S.-M.; Kanakamma, P. P.; Chen, Y.-H.; Chen, C.; Shieu, J.-C.; Yiin, S.-J.; Lee, G.-H.; Wang, Y.; Luh, T.-Y.

J. Org. Chem. 1999, 64, 532–539 [PDF]

 

1. Stereospecific Synthesis of the CP-263,114 Core Structure

Chen, C.; Layton, M. E.; Shair, M. D.

J. Am. Chem. Soc. 1998, 120, 10784–10785 [PDF] (supporting info)