Research

Current Projects

  • Genetic tools for endometrial cancer research:  We identified Sprr2f as an endometrial-specific gene and described methods for using its regulatory regions to drive expression of other genes, such as the Cre recombinase (Sprr2f-Cre).
  • Carcinosarcoma and Fbxw7:  Carcinosarcoma is the most aggressive and least understood variant of endometrial cancer, distinguished from usual endometrial cancers by admixed malignant epithelial and mesenchymal components (carcinoma and sarcoma).
  • POLE mutations and endometrial cancer:  About 10% of endometrial cancers are initiated by a mutation (most frequently P286R) in polymerase epsilon (encoded by the POLE gene).
  • Early diagnosis and prevention of endometrial cancer:  The diagnosis of endometrial precancer (endometrioid intraepithelial neoplasia/EIN) remains a challenging area, with variable criteria and frequent disagreements even among expert gynecologic pathologists, potentially leading to under/overtreatment.