I initiated a targeted CRISPR-Cas9 screen in Drosophila for germ-cell-enriched genes that are highly conserved across evolution, but remain uncharacterized. Hits from the screen provide an opportunity for breakthroughs in germ-cell biology.
I study how the germline protects the genome from damage. My research focuses on how GCNA maintains genome integrity in the germline.
I am developing a platform for in vitro gametogenesis.
I study whether specialized ribosomes exist in different cell types. I am using Drosophila to characterize ribosomal protein paralogs that exhibit enriched expression in germ cells.
I’m interested in the heterogeneity of ribosomes and its contribution to cell fate determination. Currently, I’m working on characterizing “old” versus “new” ribosomes, and uncovering the potential regulation of ribosome aging.
I am interested in how germ cells differentiate. I am characterizing the function of the beta-karyopherin protein Importin-9 and identifying its cargoes during gametogenesis.