Fibulin-5 Function in the Tumor Microenvironment

We have demonstrated previously that fibulin-5 (Fbln5) competes with fibronectin for binding to integrin α5β1. Absence or blockade of Fbln5 results in elevated ligation of the integrin by fibronectin, which stimulates the production of reactive oxygen species (ROS). We are deciphering the signaling pathways that lead to ROS production and are also exploring the physiologic consequences of fibronectin-mediated integrin-induced ROS generation.