Collagen Signaling in Tumors

Matricellular proteins are a class of ECM-related proteins that control the interaction of cells with the ECM and/or deposition of structural ECM proteins (e.g., collagens, elastin).SPARC (also known as osteonectin) is a prominent member of the matricellular class of proteins. SPARC is known to orchestrate collagen deposition and we have documented that it is required for appropriate host response to tumor growth and control of the activation of latent TGFβ. Current studies are focused on demonstrating that SPARC is a critical control point for collagen signaling.