The BICF may undertake or provide support for projects that have broad institutional benefit and fulfill institutional strategic goals. Current Flagship Projects are:
Kidney Cancer Explorer
Kidney Cancer Explorer (KCE) integrates up-to-date clinical-pathological data with high-dimensional genomics and research samples into a unified database that supports powerful analytical tools for integrative research studies. Data are extracted using automatic queries from multiple warehouses. Information can be linked to an extensive biobank including possibly the largest collection of live tumor samples and kidney cancer tumorgrafts. KCE is the result of a fruitful collaboration between the Lyda Hill Department of Bioinformatics and the Kidney Cancer Program at UT Southwestern. The project is supported by a CPRIT grant and through a Specialized Program of Research Excellence Award (SPORE) from the National Cancer Institute. UT Southwestern, is one of two institutions in the US to receive a prestigious SPORE.
The goal of the UTSW NGS CLIA Lab is to provide personalized targeted therapy for cancer patient care, the bioinformatics group provides all of the tools necessary for monitoring wet bench quality control, identifying the unique genetic makeup of tumor samples and associate genetic alternations with clinical and genetic annotations. This lab provides gene panel testing to patients at UTSW, Children’s and Parkland Hospitals.
The Medical Informatics and Genomics Group is a bioinformatics group that works in collaboration with physicians and researchers in the Departments of Immunology and Pathology as part of the UTSW CLIA Laboratory. The group is responsible for developing analysis workflows to identify variants in tumor cells including CNV, SNVs, InDels and gene fusions.
The goal of the Microbiome Research Laboratory (MRL) is to support basic and translational researchers who wish to use microbial metagenomics in their research activities. The MRL allows researchers to access a complete microbial metagenomic analysis pipeline encompassing study design, sample processing, sequencing, and bioinformatic analysis of data. Thus, the MRL aims to facilitate innovative research on the microbiome in a variety of basic, translational, and clinical fields.