My current projects are dedicated to molecular mechanisms involved in testicular germ cell tumor (TGCT) progression. TGCT is the most commonly diagnosed malignancy in men aged 15-40. There are five major histological subtypes of adult TGCT. However, multiple evidences show that all of them derived from one common precursor, germ cell neoplasia in situ (GCNIS). GCNIS is a pre-invasive state of TGCTs. My goal is to understand what external and internal factors cause GCNIS transformation.