Featured Publications

Myristoylome Profiling Reveals a Concerted Mechanism of ARF GTPase Deacylation by the Bacterial Protease IpaJ.

Burnaevskiy N, Peng T, Reddick LE, Hang HC, Alto NM Mol. Cell 2015 Mar

Bacteria Fighting Back: How Pathogens Target and Subvert the Host Innate Immune System.

Reddick LE, Alto NM Mol. Cell 2014 Apr 54 2 321-328

Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest.

Selyunin AS, Reddick LE, Weigele BA, Alto NM Cell Rep 2014 Mar 6 5 878-91

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

Burnaevskiy N, Fox TG, Plymire DA, Ertelt JM, Weigele BA, Selyunin AS, Way SS, Patrie SM, Alto NM Nature 2013 Mar

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM Cell 2012 Feb 148 4 803-15

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM Nature 2011 Jan 469 7328 107-11

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.

Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM Nat. Struct. Mol. Biol. 2009 Aug 16 8 853-60

Enteropathogenic E. coli Effectors EspG1/G2 Disrupt Microtubules, Contribute to Tight Junction Perturbation and Inhibit Restoration.

Glotfelty LG, Zahs A, Hodges K, Shan K, Alto NM, Hecht GA Cell. Microbiol. 2014 Jun

Thinking outside the Osp(G)--kinase activation by E2-ubiquitin.

de Jong MF, Alto NM EMBO J. 2014 Jan

Subversion of cell signaling by pathogens.

Alto NM, Orth K Cold Spring Harb Perspect Biol 2012 Sep 4 9 a006114