Monday March 30, 2020

Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury

Moderators: Brendan McGuire, MD (UAB) and William M. Lee, MD (UTSW)

Time Presentation Title Speaker
8-8:10 am Welcome and Introduction Brendan McGuire, MD
8:10-8:30 am Acute Liver Failure and ALFSG William M. Lee, MD
8:30-8:50 am Patterns of Liver Injury Neil Kaplowitz, MD
8:50-9:10 am Clinical Phenotypes of ALF Raj Reddy, MD
9:10-9:40 am Histopathology of ALF David Kleiner, MD
9:40-10:00 am SIRS and the Role of Infection in ALF Ariel Feldstein, MD
10:00-10:15 am Discussion  

Session 2: Liver Regeneration and Response to Injury

Moderators: Sanjeev Gupta, MD (Albert Einstein) and Michael Schilsky, MD (Yale)

Time Presentation Title Speaker
8-8:10 am Welcome and Introduction Brendan McGuire, MD
10:30-10:55am Overview of Basic Regenerative Mechanisms Sanjeev Gupta, MD
10:55-11:20 am Immunologic Basis of Liver Injury/Response Mark McPhail, MD, UK
11:20-11:40 am Plasma Cells and Injury in HBV ALF Patrizia Farci, MD
11:45-12:15 pm Bio-markers in ALF Mike Schilsky, MD
12:15-12:30 pm Discussion  

Session 3: Genomics of Liver Injury

Moderators: Raymond Chung, MD (Mass General) and Robert Fontana, MD (U Michigan)

Time Presentation Title Speaker
1:15-1:40 pm Genomics Overview Raymond Chung, MD
1:40-2:05 pm Genomics and Viral Liver Injury Laurent Casanova, MD,PhD
2:05-2:30 pm Genomics of Drug-Induced Liver Injury Paola Nicoletti, PhD
2:30-2:45 pm Discussion  

Session 4: Diagnosis and Evaluation of ALF

Moderators: Jim Hanje, MD (Ohio State) and Dan Ganger, MD (Northwestern University)

Time Presentation Title Speaker
3:00-3:25 pm Natural History of ALF Ken Simpson, MD
3:25-3:50 pm Workup of Acute Liver Failure: Checklist Oren Fix, MD
3:50-4:15 Case Presentation: New Diagnoses (HLH case) Shannan Tujios, MD
4:15-4:40 Causality: Determining Etiology in ALF Daniel Ganger, MD
4:40-5:00 pm Discussion  

Tuesday March 31, 2020

Session 5: Complications of ALF: Riding Out the Storm

Moderators: Dean Karvellas, MD (Univ. of Alberta) and Jody Olson, MD (Univ. of Kansas)

Time Presentation Title Speaker
8:00-8:25 am Critical Care of ALF: Overview Dean Karvellas, MD
8:25-8:50 am Hemostasis in ALF: Is There a Coagulopathy? R. Todd Stravitz, MD
8:50-9:10 am Fluids, Pressors, Kidney Injury Management Jody Olson, MD
9:10-9:30 am Discussion  

Session 6: Prognosis in ALF/Role of Transplantation

Moderator: Ken Simpson, MD (Edinburgh) and David Koch, MD (MUSC)

Time Presentation Title Speaker
9:45-10:10 am Prognostic Indices: Determining Outcomes David Koch, MD
10:10-10:30 am Designing Clinical Trials in an Orphan Disease Valerie Durkalski, PhD
10:30-10:55 am Methacetin Breath Test and Other Tools Robert Fontana, MD
10:55-11:20 am Outcomes of Transplantation: SRTR and ALFSG Justin Parekh, MD
10:55-11:20 am Outcomes of Transplantation: SRTR and ALFSG Justin Parekh, MD
11:20-11:45 am Is ALF Going Away? An Epidemiologist’s View Babak Orandi, MD
11:45-12:00 pm Discussion  

Session 7: The Future of ALF: Newer Modalities of Liver Support

Moderator: R. Todd Stravitz, MD (MCV) and Scott Nyberg, MD (Mayo Clinic)

Time Presentation Title Speaker
1:00-1:20 pm Liver support machines: Current status Scott Nyberg, MD
1:20-1:40 pm Stem cell recruitment for liver support Russell Wesson, MD
1:40-1:50 pm Discussion  
1:50-2:00 pm Final words William M Lee, MD


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This course/program is endorsed by AASLD. The Acute Liver Failure Study Group is pleased to have received the endorsement of the American Association for the Study of Liver Diseases (AASLD). Copyright © 2020 by the American Association for the Study Diseases. All rights reserved.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AASLD. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.