Genomic Dark Matter: Mobile Elements and Transposopathies

New technologies in genomic sciences allow us to explore the content of genomes in ways never before possible. While these advances have greatly improved our analytical power, vast portions of the genome that don't encode protein products remain mysterious. The extent of unannotated "non-coding" transcription is not accurately known, but its high activity challenges our concepts of genetic information and of the "junk DNA paradox."

Our research is moving beyond descriptive studies of "genomic dark matter" to determine how "noncanonical" RNAs might encode meaningful content.