Novel Therapeutics:
Trypt-Out: Precision Nutrition to Reset Metabolism and Starve Disease
Maralice Conacci-Sorrell, Ph.D.
- Associate Professor, Department of Developmental Biology, UT Southwestern Medical Center
Trypt-Out is a breakthrough nutritional approach that targets how the body uses the essential amino acid tryptophan. Instead of fueling healthy metabolism, excess tryptophan can be hijacked by cancer cells and metabolic disease pathways to drive fat accumulation, liver injury, and tumor growth. By selectively removing tryptophan from a protein shake, Trypt-Out triggers rapid fat loss while preserving muscle and dramatically improves fatty liver in preclinical models. Unlike weight-loss drugs that suppress appetite or cause muscle loss, this approach rewires metabolism at its source through diet alone. Trypt-Out represents a scalable, low-risk platform with potential applications across obesity, metabolic disease, and MYC-driven cancers.
