Novel Therapeutics:
Radiation-Primed In Situ Immunotherapy for Treatment-Resistant Breast Cancer
Prasanna G. Alluri, M.D., Ph.D.
- Assistant Professor, Radiation Oncology
- UT Southwestern Medical Center
Dr. Prasanna Alluri is developing a chemotherapy-free, radiation-enhanced in situ vaccine designed to treat immunologically cold breast cancers. This innovative therapy combines radiation with a BET inhibitor to prime the immune system, turning the tumor into an immune-stimulating "vaccine" site, which generates a systemic anti-tumor immune response. In preclinical models, this approach has shown to reverse resistance in breast cancer and induce durable responses without the typical toxicity of chemotherapy. Dr. Alluri’s strategy is groundbreaking, offering a short-course, non-invasive treatment that is ready to transition to IND-enabling clinical studies. The technology has strong commercial potential with numerous clinical-stage BET inhibitors already in development, making this a promising new addition to the immuno-oncology landscape.
