Research Interests
The laboratories in the Department of Pharmacology conduct research in a wide variety of fields and disciplines. A traditional focus of the Department has been molecular pharmacology and understanding the mechanisms of signal transduction.
Areas of cell signaling being investigated include:
- Signaling through G-protein coupled receptors (Ross, Smith, Sternweis, Taussig, and Wilkie)
- Nuclear hormone receptors (Kliewer, Mangelsdorf, and Wan)
- Cell-surface receptors involved in axon guidance (Zhang)
- Cell cycle regulation (Luo and Yu)
- Regulation of signaling protein function by covalent modifications (Cobb, Luo, Reese, Weaver, and Yu)
Other areas of interest include:
- Cancer biology (Cobb, Kliewer, Luo, Mangelsdorf, Martinez, Wan, and Yu)
- Chemical biology (Corey and Weaver)
- Evolutionary biology (Reese and Weaver)
- Glycobiology (Lehrman)
- Nuclear and vesicular trafficking (Albanesi, Chook, and Goodman)
- Lipid metabolism and membrane composition (Goodman)
- Parasite biology (Collins, Kliewer, Mangelsdorf, and Reese)
- Protein homeostasis (Weaver)
- Stem cell biology (Collins and Weaver)