Clinical Research

Physicians in the Division of Pediatric Hematology and Oncology are engaged in a wide range of clinical research efforts spanning the cancer and blood disease programs. Clinical research efforts are supported by robust infrastructure provided by the Clinical Research Office (CRO) within the Gill Center and the Simmons Comprehensive Cancer Center at UT Southwestern, the only NCI-designated comprehensive cancer center in North Texas. At any point, 75 to 100 oncology trials and 20 to 30 hematology trials are open for enrollment for Gill Center patients.

Active areas of clinical research include:

  • Prospective clinical trials for children with cancer, conducted under the umbrella of the NCI-sponsored Children’s Oncology Group
  • Prospective, early-phase clinical trials for children with hematological malignancies, conducted as part of the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) consortium and other academic and industry partners
  • Prospective therapeutic trials for children with sickle cell disease, iron deficiency anemia and hemophilia
  • Investigator-initiated and industry-sponsored therapeutic studies of children with cancer and blood disease
  • Retrospective research studies investigating molecular and clinical factors influencing late effects in childhood cancer survivors
  • Prospective and retrospective studies assessing a variety of quality measures of children with chronic hematology disorders
  • Early phase clinical trials of immunotherapeutics for childhood cancer, including the use of CAR T-cells for childhood leukemia
  • Prospective and translational research trials in children with venous thrombosis