UT Southwestern physicians showed likely vertical transmission of SARS-CoV-2
In a landmark case study titled “Intrauterine transmission of SARS-CoV-2 infection in a preterm infant" published online in The Pediatric Infectious Disease Journal on 07/10/2020, a multidisciplinary team of UT Southwestern physicians showed likely vertical transmission of SARS-CoV-2. The pathologic examination of the placenta provided the critical piece of information – the missing link – that helped make the case for vertical transmission. The placental examination was a collaborative effort of three of our pathologists – Dr. Rebecca Collins, Dr. Veena Rajaram, and Dr. Dinesh Rakheja. The placenta findings included histiocytic intervillositis, electron microscopic demonstration in syncytiotrophoblast of viral particles consistent with SARS-CoV-2, and the immunohistochemical demonstration of SARS-CoV-2 nucleocapsid protein in the syncytiotrophoblast cytoplasm.
The other authors on the case study include Drs. Julide Sisman, Mambarambath Jaleel, and Rashmin Savani (Division of Neonatal-Perinatal Medicine, Department of Pediatrics), Dr. Wilmer Moreno (Department of Obstetrics and Gynecology) and Dr. Amanda Evans (Division of Infectious Diseases, Department of Pediatrics).