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UT Southwestern physicians showed likely vertical transmission of SARS-CoV-2

Different Coronavirus molecules

In a landmark case study titled “Intrauterine transmission of SARS-CoV-2 infection in a preterm infant" published online in The Pediatric Infectious Disease Journal on 07/10/2020, a multidisciplinary team of UT Southwestern physicians showed likely vertical transmission of SARS-CoV-2. The pathologic examination of the placenta provided the critical piece of information – the missing link – that helped make the case for vertical transmission. The placental examination was a collaborative effort of three of our pathologists – Dr. Rebecca Collins, Dr. Veena Rajaram, and Dr. Dinesh Rakheja. The placenta findings included histiocytic intervillositis, electron microscopic demonstration in syncytiotrophoblast of viral particles consistent with SARS-CoV-2, and the immunohistochemical demonstration of SARS-CoV-2 nucleocapsid protein in the syncytiotrophoblast cytoplasm.

The paper can be accessed by clicking here.

The other authors on the case study include Drs. Julide Sisman, Mambarambath Jaleel, and Rashmin Savani (Division of Neonatal-Perinatal Medicine, Department of Pediatrics), Dr. Wilmer Moreno (Department of Obstetrics and Gynecology) and Dr. Amanda Evans (Division of Infectious Diseases, Department of Pediatrics).‚Äč