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R21 Award to Drs. Charles White and Satwik Rajaram

The National Institute on Aging has awarded an R21 grant entitled, “Quantifying the individual contributions of comorbid tau neuropathologies using deep learning” to Drs. Charles White and Satwik Rajaram. The project will use deep learning to analyze whole slide images of human brain in an effort to differentiate the neuropathologic signatures of two neurodegenerative brain disorders, Alzhiemer disease and progressive supranuclear palsy. Both of these disorders are characterized by the pathological accumulation of post-translationally modified tau protein, but the cell types affected and the clinical consequences assocated with each disease are different. The eventual goal of this project is to determine the relative contributions of each of these tauopathies to overall pathology when they occur together in the same subject. Dr. White is a Professor of Pathology and holds the Nancy R. McCune Distinguished Chair in Alzheimer’s Disease Research. Dr. Rajaram is Assistant Professor in the Lyda Hill Department of Bioinformatics and an Assistant Professor of Pathology.

Award Details

Title: Quantifying the individual contributions of comorbid tau neuropathologies using deep learning       

Project period: 2 years (9/15/20-8/31/22)

Funding level: $450,250