Dr. Hasan Zaki awarded CPRIT grant
Dr. Hasan Zaki was awarded a $900,000 / three-year grant from the Cancer Prevention Research Initiative of Texas (CPRIT) in February 2020. Despite technological advances in diagnosis and the remarkable progress in treatment options for colorectal cancer (CRC) patients, the disease remains the second leading cause of cancer-related deaths in the U.S. Dr. Zaki will investigate the cell type specific role of NLRP12, an important regulator of intestinal inflammation and tumorigenesis, in the regulation of CRC. The precise mechanism through which NLRP12 suppresses the Wnt/b-catenin pathway is unknown. By defining Wnt/b-catenin dependent and independent roles of NLRP12 in the protection against CRC, this research could improve the survivability of latter stage CRC diagnoses.