Recent discoveries from the laboratory of Ram Mani are featured by the US Department of Defense (DOD) in their website.

Dr. Ram Mani

Recent discoveries from the laboratory of Ram Mani are featured by the US Department of Defense (DOD) in their website. BRD4, a member of the Bromodomain and Extraterminal (BET) protein family, is largely recognized for its role in transcriptional regulation. Dr. Mani and his international team of collaborators have uncovered a novel DNA repair function for BRD4. These studies explain the mechanisms underlying the formation of recurrent oncogenic gene fusions, and also enhance our understanding of prostate cancer radiation therapy outcomes.