Pathology faculty Drs. Castrillon and Mani receive 2019 Cancer Prevention and Research Institute of Texas (CPRIT) award

Drs. Castrillon and Mani

Congratulate Drs. Castrillon and Mani-each received $900,000 Individual Investigator Awards from the Cancer Prevention and Research Institute of Texas (CPRIT) for 2019.   The award will assist Dr. Diego Castrillon's study of the role of the Fbxw7 tumor suppressor in carcinosarcoma, the most aggressive form of endometrial cancer, also known as uterine cancer. The project will make use of a novel genetically-engineered mouse model and translational studies of patient samples. Dr. Castrillon, a Professor of Pathology, holds the Vernie A. Stembridge, M.D., Distinguished Chair in Pathology.

Dr. Ram Mani’s  award will help his laboratory construct three-dimensional genome contact maps of CTCF, a protein that mediates looping interactions that genes use to interact with regulatory DNA elements. These looping interactions are often hijacked by cancer. Dr. Mani will study this process in prostate cancer. He is an Assistant Professor of Pathology and Urology.