Methylation of Hypoxia Inducible Factor
Luo/Wang Labs recently discovered a new molecular mechanism that negatively controls the activity of HIF-1 protein and movement of glioblastoma cells under hypoxic conditions, which was published online on Nucleic Acids Research. They found that two enzymes G9a and GLP methylate HIF-1alpha protein in glioblastoma cells. Methylated HIF-1alpha protein loses its activity to induce the expression of genes that are involved in cell movement, leading to impaired migration of glioblastoma cells. This study uncovers the new possible therapeutic targets for the treatment of glioblastoma.
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